I have done basically that before and it worked. But I find Tailscale with a headscale server easier to manage. Maybe I’ll take a look into selfhosting netbird at some point too.

Apart from the dependency stuff, what you need to migrate when you use docker-compose is just a text file and the volumes that hold the data. No full VMs that contain entire systems because all that stuff is just recreated automatically in seconds on the new machine.