My work flow depends heavily on Win + V and Win + Shift + S, both on my main desktop and RDP’ed into other Windows systems while sharing a clipboard. I’m interested in trying Linux as my daily driver, and I am looking for suggestions that will offer the least friction in how I operate. The above items are must haves and my hope is that the solution “just works” without having to set up a whole mess of macros or workarounds.
I am familiar with Debian and Ubuntu, so Linux will not be a new experience for me, though most of my work has been from command line interactions. My hope would be a distro I can stand up in a few hours that will let me continue to RDP into Windows systems and keep using Windows hot keys on both the Linux desktop and the Windows systems.


KDE is the way to go, it works great and is highly customizable to your liking. As for a distro, it’s a little more difficult.
I, for instance, have no issues with CachyOS, but there might be better alternatives I don’t know. Maybe others know some great distros.
What you can do, however, is set up a VM to try out a couple of KDE distros.