Generally a high vote count is supposed to be primarily used to tell a user that:

• this comment was made by a human
• it is on topic to the conversation
• it contributes to the conversation in a way that encourages further conversation
• it is factually true, or it is not factually true but the user didn’t know initially and was later corrected

Usually, a low negative vote count is supposed to mean:

• this comment was made by a bot
• it is off topic
• it is a thread dead end
• it is factually false, or the user knew it was factually false and did not correct it

It shoupd be noted that “factually true/false” does not mean “I think this or that” or “this isnt that because,” it means “this is wrong and here is the verifiable source link.” The conversations where votes tend to most often break these general points are political or emotional in nature, where a “factual truth may not exist for both sides or multiple different truths exist (ie, political ideologies ignoring something from ‘the other side’),” rather than something like scientific discussion where there is only one singular factual truth on a matter.

Of course, these have become so diluted now that negative votes on a comment could mean anything from “I dont agree with this users politics and didn’t read past the first sentence before voting” to “this comment was already downvoted when I got here so I just downvoted it again without reading what it says because everyone else must be right.”