“inflammation is now understood to be a key mediator of OA that contributes to cartilage loss and progressive degeneration of affected joints… OA is no longer considered a noninflammatory arthritis or a ‘wear and tear’ disease”
I heretofore thought age-related cartilage loss was the cause of osteoarthritis and inflammation. Turns out it’s the other way around: the inflammation degrades cartilage. Okay, no more slogging through joint pains for me, regardless of how small.
Edit: added a phrase for clarity
This is a field I study. Its more complicated than yes/no. OA is caused by inflammation. However, inflammation when introduced into a joint space raises the friction coefficient between surfaces within the joint. More friction leads to mechanical stress and deterioration.
The friction coefficient for synovial joints ranges from 0.0015 - 0.01 depending on the study. Essentially frictionless. That’s why when inflammation enters the synovial fluid, you hear crepitus or “creaking”. Friction goes up and tendons vibrate like strings on a violin. For reference, ice on a Teflon pan has a friction coefficient of 0.05 - 0.10. Roughly ×5 the conservative estimate for synovial joints.
Had the chance to do cadaver dissections and synovial fluid is some fascinating stuff! Slightly mucusy, but incredibly slick
